Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.
prospective_cohort · Level II
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Abstract
We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.
Medical subject headings
- Genetic Counseling
- Glycine
- Parkinson Disease
- Penetrance
- Protein Serine-Threonine Kinases
- Serine