A circadian sleep disorder reveals a complex clock.
basic_science · Level V
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- Record sourced from PubMed, PMID 17218251.
- Also identified by PMC identifier 3758472.
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Abstract
Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.
Medical subject headings
- Biological Clocks
- Nuclear Proteins
- Sleep Disorders, Circadian Rhythm
- Transcription Factors