PTEN enters the nuclear age.
editorial · Level V
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Abstract
Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.
Medical subject headings
- Cell Nucleus
- PTEN Phosphohydrolase