Transposon-tagged mutagenesis in the rat.
basic_science · Level V
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- Record sourced from PubMed, PMID 17220894.
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Abstract
Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model.
Medical subject headings
- Animals, Genetically Modified
- DNA Transposable Elements
- Mutagenesis, Insertional
- Rats