Adenosine in burn blister fluid.
case_series · Level IV
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- Record sourced from PubMed, PMID 17234350.
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Abstract
Burn wound blister fluid is known to sustain suppressive effects on various components of the immune system. Damaged tissues cause an increase of adenosine concentrations. Since adenosine is a potent anti-inflammatory agent we hypothesized that burn blister fluid contains high concentrations of this nucleoside. Burn blister fluid was drawn from eleven patients who suffered a second degree burn injury. Adenosine concentrations were determined using high performance liquid chromatography (HPLC). Elevated adenosine levels were detected in 6 of the 11 patients (54.5%), with an overall mean of 1.13+/-0.52 mM. This is the first documented data showing increased concentrations of adenosine in burn blister fluid.
Medical subject headings
- Adenosine
- Blister
- Burns