Is Her-2/neu expressed in nonepithelial ovarian malignancies?
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 17240244.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.
Medical subject headings
- Genes, erbB-2
- Granulosa Cell Tumor
- Neoplasms, Germ Cell and Embryonal
- Ovarian Neoplasms