Estimation of the rate of killing by cytotoxic T lymphocytes in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17242364.
- Also identified by PMC identifier 1785271.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells. How fast do CTL find and kill target cells in vivo? Experiments allow us to follow populations of labeled target cells after their transfer into immune mice where they are killed by CTL. Here, we develop models of the migration and killing processes involved in these experiments and use them to quantitatively analyze the in vivo killing data. These models allow us to estimate the rate constant for killing of target cells by CTL.
Medical subject headings
- Models, Immunological
- T-Lymphocytes, Cytotoxic