In vitro studies of elastin-fibrin biomaterial degradation: preservative effects of protease inhibitors and antibiotics.
basic_science · Level V
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Abstract
The degradability of a new elastin-fibrin material was tested in vitro versus human pancreatic elastase (HPE) and plasmin (PL) activities. It is shown that aprotinine Iniprol, a well-known protease inhibitor and Eglin C, a new potent inhibitor of HPE, especially when used in synergy, efficiently protected the material. A small amount of specific antibiotics was incorporated into the material. The two products will allow the material to be used in digestive surgery with improved safety.
Medical subject headings
- Anti-Bacterial Agents
- Biocompatible Materials
- Elastin
- Fibrin
- Protease Inhibitors
- Serpins