Mathematical models of the VEGF receptor and its role in cancer therapy.
basic_science · Level V
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- Record sourced from PubMed, PMID 17251148.
- Also identified by PMC identifier 2359839.
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Abstract
We present an analysis of a stochastic model of the vascular endothelial growth factor (VEGF) receptor. This analysis addresses the contribution of ligand-binding-induced oligomerization, activation of src-homology 2 domain-carrying kinases and receptor internalization in the overall behaviour of the VEGF/VEGF receptor (VEGFR) system. The analysis is based upon a generalization of a Wentzel-Kramers-Brillouin (WKB) approximation of the solution of the corresponding master equation. We predict that tumour-mediated overexpression of VEGFRs in the endothelial cells (ECs) of tumour-engulfed vessels leads to an increased sensitivity of the ECs to low concentrations of VEGF, thus endowing the tumour with increased resistance to anti-angiogenic treatment.
Medical subject headings
- Endocytosis
- Models, Biological
- Neoplasms
- Receptors, Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor A
- src Homology Domains