Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.
case_report · Level V
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Abstract
We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril. The lactic acidosis was successfully treated with early high-volume continuous veno-venous haemofiltration. Rhabdomyolysis and lower limb compartment syndrome developed later. The patient otherwise made a good recovery. We discuss the management of severe lactic acidosis secondary to metformin overdose and the association with rhabdomyolysis.
Medical subject headings
- Acidosis, Lactic
- Antihypertensive Agents
- Hypoglycemic Agents
- Metformin
- Ramipril
- Rhabdomyolysis