Oncogene-induced senescence pathways weave an intricate tapestry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17254959.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.
Medical subject headings
- Cell Transformation, Neoplastic
- Cellular Senescence
- Oncogenes
- Protein Serine-Threonine Kinases
- Tumor Suppressor Protein p53