Phosphoinositides specify polarity during epithelial organ development.
basic_science · Level V
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Abstract
The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.
Medical subject headings
- Cell Polarity
- Epithelium
- Organogenesis
- Phosphatidylinositols
- Signal Transduction