Another piece of the p27Kip1 puzzle.
basic_science · Level V
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- Record sourced from PubMed, PMID 17254963.
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Abstract
How extracellular signals communicate with the cell cycle is poorly understood. In this issue, two papers address this problem by reporting phosphorylation of the cyclin-dependent kinase inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stability. This new mechanism could explain how cells enter the cell cycle from a quiescent state.
Medical subject headings
- Cell Cycle
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p27
- Extracellular Space
- Signal Transduction