Artificial reporter gene providing MRI contrast based on proton exchange.
basic_science · Level V
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Abstract
Existing magnetic resonance reporter genes all rely on the presence of (super)paramagnetic substances and employ water relaxation to gain contrast. We designed a nonmetallic, biodegradable, lysine rich-protein (LRP) reporter, the prototype of a potential family of genetically engineered reporters expressing artificial proteins with frequency-selective contrast. This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off.
Medical subject headings
- Brain Neoplasms
- Contrast Media
- Genes, Reporter
- Glioma
- Image Enhancement
- Lysine
- Magnetic Resonance Imaging