Brain injury after intracerebral hemorrhage: the role of thrombin and iron.
review · Level V
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Abstract
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.
Medical subject headings
- Brain Injuries
- Cerebral Hemorrhage
- Iron
- Thrombin