Too stringent patient selection criteria in a clinical trial of alpha-blockers reduce the value of the results.

Rosenbaum, T P; Shaw, P J · Eur Urol · 1991

rct · Level II

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Abstract

The patient selection criteria in a clinical trial of an alpha-blocker for the treatment of benign prostatic hypertrophy were such that 85% of the patients on the waiting lists of 4 hospitals had to be excluded. The value of such a trial is discussed. Trial protocols should be designed to allow the enrollment of patients truly representative of the patients for which the treatment is intended.

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