Combination therapy for chronic hepatitis B: simultaneous or sequential?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 17266690.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Various regimens of combination or sequential therapy using nucleoside/nucleotide analogues (NAs) and interferon-alfa (IFN-alpha) have been tried for the treatment of chronic hepatitis B. To date, combination therapy of two NAs and of IFN-alpha and NAs fails to achieve extra viral suppression. Sequential therapy with lamivudine followed by IFN-alpha seems to have better sustained virologic response. However, the long-term beneficial effect of using this approach remains to be defined.
Medical subject headings
- Antiviral Agents
- DNA, Viral
- Hepatitis B, Chronic
- Interferon-alpha
- Lamivudine