An intrinsic host defense against HIV-1 integration?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17273551.
- Also identified by PMC identifier 1783824.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
HSCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21(Waf1/Cip1/Sdi1) (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.
Medical subject headings
- HIV-1
- Virus Integration