A helping hand for cytochrome p450 enzymes.
editorial · Level V
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- Record sourced from PubMed, PMID 17276348.
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Abstract
In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.
Medical subject headings
- Cytochrome P-450 Enzyme System