The metabolic sensor GCN2 branches out.
editorial · Level V
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- Record sourced from PubMed, PMID 17276350.
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Abstract
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
Medical subject headings
- Lipid Metabolism
- Protein Serine-Threonine Kinases