Visualizing the histone code on LSD1.
basic_science · Level V
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Abstract
In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.
Medical subject headings
- Estrogen Receptor alpha
- Gene Expression Regulation
- Histone Code
- Histones
- Oxidoreductases, N-Demethylating