Molecular events underlying pregnancy-induced cardiomyopathy.
editorial · Level V
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Abstract
The etiology of cardiomyopathy in pregnant women remains unclear. In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease. Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease.
Medical subject headings
- Cardiomyopathies
- Cathepsin D
- Pregnancy Complications, Cardiovascular
- Prolactin
- Puerperal Disorders
- STAT3 Transcription Factor