Tuning bulk electrostatics to regulate protein function.
basic_science · Level V
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Abstract
Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. Strickfaden et al. (2007) now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Cyclin-Dependent Kinases
- Cyclins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins