Using nitric oxide to treat tendinopathy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 17289859.
- Also identified by PMC identifier 2658939.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nitric oxide (NO) is a small free radical generated by a family of enzymes, the nitric oxide synthases (NOSs). Following injury to a tendon, NO is induced by all three isoforms of NOS and NOS activity is also upregulated in tendinopathy. In animal models when NOS activity is inhibited by competitive inhibitors of NOS, tendon healing is reduced. When additional NO is added, tendon healing is enhanced. In humans, in three randomised clinical trials, we have shown that NO delivered via a transdermal patch enhances the subjective and objective recovery of patients with tennis elbow, Achilles tendinosis and supraspinatus tendinosis.
Medical subject headings
- Free Radical Scavengers
- Nitric Oxide
- Nitric Oxide Synthase
- Tendinopathy
Anatomy
- shoulder