The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.
editorial · Level V
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Abstract
Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.
Medical subject headings
- Galactosyltransferases
- Genetic Predisposition to Disease
- Glomerulonephritis, IGA
- Immunoglobulin A