Genome regulation by polycomb and trithorax proteins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17320510.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.
Medical subject headings
- Chromosomal Proteins, Non-Histone
- Drosophila Proteins
- Epigenesis, Genetic
- Gene Expression Regulation, Developmental
- RNA Interference
- Repressor Proteins