The development of a bioengineered organ germ method.
basic_science · Level V
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- Record sourced from PubMed, PMID 17322892.
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Abstract
To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.
Medical subject headings
- Bioartificial Organs
- Epithelial Cells
- Mesenchymal Stem Cells
- Organogenesis
- Tissue Engineering
- Tooth
- Vibrissae