Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications.
review · Level V
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Abstract
Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as one of the common pathways in cancer cells. Stat3 signaling affects the expression and function of a variety of genes that are critical to cell survival, cell proliferation, invasion, angiogenesis, and immune evasion. Evidently, the Stat3 signaling pathway regulates cancer metastasis and constitutes a potential preventive and therapeutic target for cancer metastasis.
Medical subject headings
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasms
- STAT3 Transcription Factor
- Signal Transduction