BuMP-ing up insulin secretion by pancreatic beta cells.
other · Level V
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- Record sourced from PubMed, PMID 17339021.
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Abstract
While several transcription factors are known to increase insulin production and secretion, their therapeutic potential for treatment of type 2 diabetes remains unrealized. In this issue, Goulley et al. (2007) show that BMP signaling specifically regulates genes involved in insulin production and secretion and demonstrate that exogenous BMP4 administration augments glucose-stimulated insulin secretion in vivo.
Medical subject headings
- Bone Morphogenetic Protein Receptors, Type I
- Bone Morphogenetic Proteins
- Insulin
- Insulin-Secreting Cells