Molecular dissection of the secretory pathway.

Rothman, J E; Orci, L · Nature · 1992

basic_science · Level V

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Abstract

A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.

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