Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 17344566.
- Also identified by PMC identifier 2599992.
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Abstract
A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an uneventful recovery with the withdrawal of simvastatin. It is likely that this complication will be seen more often with the increased worldwide use of this drug and its approval for all arteriopathic patients.
Medical subject headings
- Anticholesteremic Agents
- Compartment Syndromes
- Hypercholesterolemia
- Hypothyroidism
- Muscle, Skeletal
- Simvastatin