Renal response to repeated exposure to endotoxin: implications for acute kidney injury.
editorial · Level V
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Abstract
Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.
Medical subject headings
- Endotoxins
- Kidney
- Kidney Diseases
- Lipopolysaccharides