From stem cell to progenitor and back again.
review · Level V
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Abstract
Under normal homeostatic conditions, tissue stem cells undergo long-term self renewal and produce progeny that differentiate into several different cell types. But what happens if the stem cells are lost? In a recent issue of Developmental Cell, Nakagawa et al. (2007) propose that the progeny of stem cells, called transit-amplifying progenitor cells, are able to replace lost stem cells.
Medical subject headings
- Adult Stem Cells
- Multipotent Stem Cells
- Testis