Innate response to self-antigen significantly exacerbates burn wound depth.
basic_science · Level V
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- Record sourced from PubMed, PMID 17360462.
- Also identified by PMC identifier 1820693.
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Abstract
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
Medical subject headings
- Autoantigens
- Burns
- Complement System Proteins
- Wound Healing