Argonautes and company: sailing against the wind.
basic_science · Level V
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Abstract
The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.
Medical subject headings
- 3' Untranslated Regions
- Gene Expression Regulation
- Peptide Initiation Factors
- RNA-Binding Proteins
- Tumor Necrosis Factor-alpha