The tail end of membrane insertion.
basic_science · Level V
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Abstract
Many membrane proteins are inserted into cellular membranes via a carboxy-terminal tail-anchor segment, but the mechanism of insertion is poorly understood. In this issue of Cell, Stefanovic and Hegde (2007) report the identification and initial characterization of a soluble ATP-dependent receptor for the insertion of newly synthesized tail-anchored membrane proteins.
Medical subject headings
- Arsenite Transporting ATPases
- Endoplasmic Reticulum
- Intracellular Membranes
- Membrane Proteins