A Bcl-xL timer sets platelet life span.
basic_science · Level V
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Abstract
Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-x(L) that cause accelerated death of platelets leading to platelet deficiency.
Medical subject headings
- Blood Platelets
- bcl-X Protein