Resolution of pityriasis rubra pilaris-induced cicatricial ectropion with systemic low-dose methotrexate.

Abstract

To report a case of pityriasis rubra pilaris (PRP)-induced bilateral lower eyelid cicatricial ectropion that resolved with systemic low-dose methotrexate. Observational case report. A retrospective case review of a patient with cicatricial ectropion caused by PRP. A 82-year-old female presented with bilateral lower eyelid cicatricial ectropion secondary to PRP. The patient did not systemically respond to conventional oral retinoid therapy. She was treated with low-dose methotrexate and experienced dramatic resolution of her signs and symptoms, including complete resolution of her bilateral cicatricial ectropion. Systemic treatment of PRP with low-dose methotrexate may result in successful treatment of cicatricial ectropion without surgery.