Renal ischemia-reperfusion injury: renal dendritic cells loudly sound the alarm.

Nelson, P J · Kidney Int · 2007

editorial · Level V

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Abstract

Renal ischemia-reperfusion injury is a major cause of acute renal failure and kidney allograft dysfunction. Dong and colleagues now identify the surveying renal dendritic cell network as the predominant source of tumor necrosis factor-alpha during the early stages of renal ischemia-reperfusion injury, raising the possibility for direct targeting of renal dendritic cells to help ameliorate this common form of renal injury and its sequelae.

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