How a home-grown T cell receptor interacts with a foreign landscape.
basic_science · Level V
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Abstract
The ability of a T cell receptor (TCR) to directly recognize foreign (allogeneic)-major histocompatibility complex (MHC) molecules underlies T cell-mediated rejection in patients receiving allogeneic organ transplants. In this issue, Colf et al. (2007) reveal that instead of mimicking the interactions formed with a self MHC, a single TCR adopts a completely different strategy to recognize a foreign MHC.
Medical subject headings
- Autoantigens
- Isoantigens
- Major Histocompatibility Complex
- Receptors, Antigen, T-Cell