IKKalpha at the crossroads of inflammation and metastasis.
basic_science · Level V
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Abstract
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
Medical subject headings
- I-kappa B Kinase
- Inflammation
- Neoplasm Metastasis
- Prostatic Neoplasms