Development in motion: helper T cells at work.
review · Level V
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- Record sourced from PubMed, PMID 17418783.
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Abstract
In mammals, helper T cells orchestrate defense against diverse pathogens. However, these warriors of the immune system can also result in self-inflicted injury culminating in autoimmune and allergic diseases. Recent findings--such as the discovery of the Th17 lineage--have revealed additional complexity in the fates chosen by helper T cells and have begun to reshape our view of how signaling and transcriptional networks generate appropriate and inappropriate immunity.
Medical subject headings
- T-Lymphocyte Subsets
- T-Lymphocytes, Helper-Inducer