A model system for analyzing somatic mutations in Drosophila melanogaster.
basic_science · Level V
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- Record sourced from PubMed, PMID 17435764.
- Also identified by PMC identifier 2723853.
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Abstract
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.
Medical subject headings
- Drosophila melanogaster
- Lac Operon
- Mutation