Patterning of frontal cortex subdivisions by Fgf17.
basic_science · Level V
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- Record sourced from PubMed, PMID 17442747.
- Also identified by PMC identifier 1863435.
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Abstract
The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.
Medical subject headings
- Body Patterning
- Fibroblast Growth Factors
- Frontal Lobe