Zfx: at the crossroads of survival and self-renewal.
basic_science · Level V
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Abstract
As the molecular mechanisms that govern stem cell fate are beginning to be unraveled, Galan-Caridad et al. (2007) report in this issue of Cell a common role for the transcription factor Zfx in the self-renewal/maintenance of both embryonic stem cells and hematopoietic stem cells. Their work suggests that a regulator of self-renewal can be shared between two different cell types.
Medical subject headings
- Cell Survival
- Embryonic Stem Cells
- Hematopoietic Stem Cells
- Kruppel-Like Transcription Factors