Targeting the sticky fingers of HIV-1.
basic_science · Level V
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- Record sourced from PubMed, PMID 17448985.
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Abstract
Although human blood plasma contains molecules that inhibit the activity of HIV-1, their identity is largely unknown. Münch et al. (2007) now identify a peptide corresponding to a portion of alpha1-antitrypsin that potently inhibits entry of HIV-1 into host cells by binding to a hydrophobic segment of the viral envelope glycoprotein gp41.
Medical subject headings
- HIV Fusion Inhibitors
- HIV Infections
- HIV-1
- Peptide Fragments
- Virus Internalization
- alpha 1-Antitrypsin