Diabetes: caught in the Akt?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 17457328.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
One complication of diabetes is a pronounced renal cellular hypertrophy, inevitably resulting in chronic fibrotic changes. Chuang and colleagues demonstrate that hypertrophy in vitro is dependent on an increased phosphoinositide 3-kinase (PI3K) activity and is correlated with increased levels of p21(WAF1/Cip1), a cell-cycle regulator that was previously associated with renal fibrosis and sclerosis from nondiabetic causes.
Medical subject headings
- Diabetic Nephropathies
- Glucose
- Kidney Diseases
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins c-akt