BDNF instructs the kinase LKB1 to grow an axon.
basic_science · Level V
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- Record sourced from PubMed, PMID 17482540.
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Abstract
Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1.
Medical subject headings
- Axons
- Brain-Derived Neurotrophic Factor
- Hippocampus
- Neurons
- Protein Serine-Threonine Kinases