Paradoxes of the EphB4 receptor in cancer.
review · Level V
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- Record sourced from PubMed, PMID 17483308.
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Abstract
Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. Understanding the multifaceted role of EphB4 in tumorigenesis may allow the development of new anticancer therapies.
Medical subject headings
- Breast Neoplasms
- Mammary Neoplasms, Experimental
- Receptor, EphB4