AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes.
other · Level V
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- Record sourced from PubMed, PMID 17485433.
- Also identified by PMC identifier 5947781.
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Abstract
The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to detect. To address these issues, we have developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples. http://www.sanger.ac.uk/genetics/CGP/Software/AutoCSA.
Medical subject headings
- Algorithms
- Chromosome Mapping
- DNA Mutational Analysis
- DNA, Neoplasm
- Genetic Testing
- Neoplasms